Eye Health

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The Evolution of Cataract Surgery

Lorne Bellan, MD, FRCSC, Acting Department Head, Department of Ophthalmology, Misericordia Health Centre, Winnipeg, MB.

In addition to the clinical presentation and diagnosis of cataracts, a summary of the development of cataract surgery is presented. Indications for cataract surgery are now based on subjective visual impairment rather than measured visual acuity. Cataract surgery can now be done safely through 3mm self-sealing incisions with excellent results and rapid recovery.
Key words: cataract, lens, phacoemulsification, visual acuity, red reflex.

Diagnosis and Management of Glaucoma

Catherine M. Birt, MD, FRCSC, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, ON.

Primary open angle glaucoma (POAG) is a disease of the optic nerve head, frequently but not always associated with elevated intraocular pressure. This article discusses the presentation and risk factors associated with POAG, how the diagnosis is made by the ophthalmologist, and the current medical management of the disease.
Key words: primary open angle glaucoma, risk factors, anti-glaucoma medications.

The Acute Red Eye in the Elderly

Robert J. Campbell MD, MSc and William G. Hodge MD, PhD, FRCSC, University of Ottawa Eye Institute, Ottawa, ON.

The differential diagnosis of the red eye involves structures ranging from the periorbita, lids and conjunctiva, to the surface sclera and episclera, to the cornea and uvea and to acute angle closure glaucoma. The history and physical examination can usually differentiate these entities from one another. The most important part of the examination is the visual acuity, which can usually distinguish the serious red eye from more benign causes.
Key words: orbital cellulites, conjunctivitis, blepharitis, keratitis, acute glaucoma, red eye.

Age-Related Macular Degeneration: An Update on Nutritional Supplementation

Sohel Somani, MD, Senior Resident, Department of Ophthalmology, University of Toronto, Toronto, ON.

Age-related macular degeneration (ARMD) is a progressive disease affecting the central vision of patients older than 55 years. Typically, ARMD patients are classified into dry and wet forms based on clinical characteristics. This has important implications with respect to their clinical presentation, prognosis and management options. Important risk factors in the progression of disease include age, smoking and drusen characteristics. The promising results of a new study on vitamin supplementation provide direction for treatment and prevention, as well as the understanding of the role of antioxidants in ARMD pathogenesis. High-dose vitamins (beta- carotene, vitamins C and E and zinc) should be considered in certain patients with ARMD.
Key words: macular degeneration, vitamins, low vision, supplementation, Amsler grid.

Beyond the Inability to See and Hear

 

As I write this editorial, Ontario health care providers and, in particular, those in the Greater Toronto Area are being overwhelmed with cases of Severe Acute Respiratory Syndrome (SARS). Not unexpectedly, the deaths caused by this illness are concentrated in the older age group. This is likely due to the comorbidity that frequently accompanies the aging process. Infectious disease specialists have been warning for many years of the danger of new infectious diseases, but for some reason we did not "see" this outbreak coming until a major public health crisis had already occurred. This is clearly an excellent illustration of the old aphorism that "there are none so blind as those who will not see".

Very real problems with sight, as well as with hearing, are all too common among our elderly patients. Vision and hearing are often grouped together as the "special senses", and they truly are special. Vision and hearing are the means through which we relate to our environment and to other people, and impairments in these spheres result in dysfunction in many areas. In geriatric medicine we know that impaired mobility and falls are closely related to visual loss. Patients with even the mildest cognitive impairment are much more likely to have hallucinations if they have associated visual impairment, while patients with hearing loss are much more likely to have paranoid ideation than those with normal hearing (hardly surprising, as they feel nobody is telling them anything!). Both hearing impairment and visual loss predispose elderly people to delirium when they become ill for any reason, which should come as no surprise as severe sensory deprivation can often provoke a delirium-like state even in young and healthy individuals. Clearly the dysfunction wrought by eye and ear diseases goes well beyond the inability to see and hear.

This issue focuses on eye and ear diseases. Dr. Sohel Somani reviews a topic that has been in the spotlight recently, the role of nutritional supplementation in age-related macular degeneration. I started practising geriatric medicine in 1979, and I believe the greatest advance in the care of elderly patients in the time between then and now has been the development of modern cataract surgery and intraocular lens implantation. Dr. Lorne Bellan reviews the evolution of modern cataract surgery, Dr. Catherine Birt provides an excellent and important article on the diagnosis and management of glaucoma, while Drs. Robert Campbell and William Hodge tackle the issue of the acute red eye in the elderly.

Of course, we cannot forget the ear in this issue. As a geriatrician, I go into "geriatric speak" when I deal with elderly patients almost without realising I'm doing it. I speak more slowly, more distinctly, and louder. The latter is not always necessary, as many older patients remind me not to shout. However, it is very clear that age-related hearing loss is a major public health concern. In our biology of aging column, Drs. Christopher Danner and Jeffrey Harris discuss hearing loss and the aging ear. Drs. Doron Milstein and Barbara Weinstein describe the role of amplification in presbycusis (presumably in a more sophisticated manner than my office shouting), and Marian McLeod provides a description of the Canadian Hearing Society's Hearing Care Counselling Program for our patients.

Please enjoy this issue.

Cataract Surgery May Cut Crash Risk

Cataracts are the leading cause of blindness in the world and account for 15% of blindness in Canada. The condition, which results in deficits in acuity and contrast sensitivity and increased disability glare, is present in half of adults over the age of 65 years. Older drivers with cataract are more likely to have a history of recent driving accidents compared with older drivers without impaired vision, yet it has not been determined whether the surgical removal of cataracts--a highly successful treatment--reduces the likelihood of crashing. Investigators set out to determine the impact of cataract surgery on the crash risk for older adults in the years following surgery, compared with that of older adults with cataracts but who opted not to have surgery.

The prospective cohort study recruited 277 patients aged 55 to 84 with cataract, 174 of whom elected to undergo surgery. Researchers followed the patients for four to six years and compared vehicle crash occurrence involving patients who elected to have surgery versus those who did not.

Results showed that people who underwent surgery were 53% less likely to be involved in a car crash than those who did not have surgery, which translated to five crashes per million miles of travel among recipients of surgery compared to nine crashes per million miles for those who declined surgery. However, the authors, aware of the study's limitations, caution against the inference that surgery can make people better drivers. Patients who opted out of surgery may have had other medical risk factors that influenced both their decision to avoid the procedure and their risk of car crashes. Therefore, while the study may indicate that driving performance of older drivers with cataracts might improve after surgery, the threat of selection bias prevents more firm conclusions.

Source

  1. Owsley C, McGwin G, Sloane M, et al. Impact of cataract surgery on motor vehicle crash involvement by older adults. JAMA 2002;288:841-9.

A Marker for Blindness

Scientists at the Tufts University School of Medicine in Boston have located a protein that may serve as the first molecular marker for the disease glaucoma, and may lead to the development of an early screening test for the disease. Dr. Joel Schuman and colleagues have discovered that the endothelial leukocyte adhesion molecule 1 (ELAM-1), a small cell adhesion molecule that is implicated in the development of vascular diseases, is present in the eyes of patients with glaucoma, but not present in healthy eyes.

The glaucomas, characterized by cupping of the optic nerve head and irreversible loss of retinal ganglion cells, comprise the leading cause of irreversible blindness worldwide. A major risk factor for development of the disease is elevated introcular pressure due to a reduction in normal aqueous outflow. The trabecular meshwork [TM] of the eye forms part of the outflow pathway for aqueous humour as it drains from the back of the eye. If the outflow of the humour is obstructed, the intraocular pressure may rise and glaucoma may occur. ELAM-1 was found to be consistently present on the TM cells in the outflow pathways of eyes with glaucomas of diverse etiology. This study provided the first evidence on a molecular marker for glaucoma, and the first evidence that common mechanisms contribute to the pathophysiology of the glaucomas and vascular diseases. It is believed that abnormalities in the genes encoding ELAM-1 may be considered to be a diagnostic marker of glaucoma, before any damaging rise in intraocular pressure is observed.

Source

  1. Wang, N et al. Nature Medicine 2001;7:304-309.

Serendipity and the Origin of the Lens Implant in Cataract Treatment

In 1942, a young British flight surgeon, Ridley, made an outstanding discovery that was to shape the future of cataract treatment. Cataracts result from the clouding of the lens of the eye, which leads to blurred vision. As with the lens of a camera, the lens of the eye functions by focussing light rays onto the retina at the back of the eye, which then transmits this visual information to the brain. For the light to pass through and reach the retina, the lens must remain clear. Cataracts result when the natural lens of the eye becomes cloudy; they are not the product of a growth or the accumulation of film over the eye.

While examining injured fighter pilots, Ridley noted that when plastic slivers from the shattered windshield of an airplane cockpit entered the eye, some pilots had a severe reaction, whereas other pilots had no reaction at all. At the time, the accepted belief was that any foreign material entering the eye would cause a severe reaction until it was removed. Ridley wanted to understand why some pilots showed no reaction to the presence of a piece of plastic in their eye. Further investigation led him to realize that it was only the pilots of Spitfires who did not suffer any complications, whereas pilots flying all other British fighter planes--including captured German pilots flying Messerschmitts--were all severely affected. The young surgeon then discovered that Spitfire plastic came from a different company, ICI, that produced a type of plastic material, polymethyl methacrylate, which could be tolerated by the human eye.

When the war ended in 1945, Ridley turned his attention to cataract surgery. Treatment at the time involved removing the diseased cataract lens and giving the patient thick, heavy glasses that limited their peripheral vision and magnified objects by 30 %. Ridley decided that a better technique for cataract treatment would be to replace the human lens with a lens made of the plastic that he had discovered during the war. On 19 November 1949, at St. Thomas's Hospital in London, he performed the first lens implant on a cataract patient.

Today the treatment of cataracts still relies solely on surgical techniques; there is no medication or diet that can stop a cataract once it has begun to form. A cataract may develop rapidly over a period of a few months or it may grow very slowly over several years. Typically, this process only occurs in a single eye, although eventually, often after months or years, a cataract may develop in the second eye. Most cataracts are related to aging, although they may also be congenital, the result of a medical problem such as diabetes or of a trauma to the eye.

A cataract rarely causes damage if it is left in the eye, except in cases in which there is blurred vision. There are very rare cases, however, of cataracts, when left in the eye long past the stage of blindness, causing inflammation and glaucoma. With the current methods of removal, surgery can be performed successfully at any stage of cataract development.

The only treatment for a cataract is the removal of the cloudy lens. There are various methods of surgically removing a cataract, and the specialist must decide which method is most suitable for each individual patient. For a description of the three main surgical procedures that are available for cataract extraction, and a list of the advantages and disadvantages of these techniques, please see the full article by Dr. Marvin Kwitko on our web site at www.geriatricsandaging.ca.

Dr. Marvin Kwitko performed his first lens implant operation at Bellechasse Hospital in Montreal in 1967. In 1968 he joined St. Mary's Hospital, and under the former chief, Dr. Gaston Duclos, continued this work there. Dr. Kwitko has trained more than 350 surgeons from Canada, the U.S. and abroad. He is currently the Chief of Opthalmology at St. Mary's Hospital in Montreal and an Associate Professor of Ophthalmology at McGill University.

Overcoming Glaucoma: Laser versus Incisional Surgical Approaches


Choice of Treatment is not Limited by Age but is Case-Specific

Robert M Schertzer, MD, FRCSC
Glaucoma & Anterior Segment Surgery
Multimedia Technology
Medical Director Visual Field and Optic Nerve Head Imaging Units
VHHSC/UBC Eye Care Centre

When pharmaceutical treatment of glaucoma proves ineffective, several surgical options remain available. In fact, some types of glaucoma may be best handled with immediate surgical intervention, even without prior medical management. Ocular surgery is any procedure that causes an alteration in the structure of the eye and can be laser (using a light) or incisional (using microsurgical blades). The type of surgical intervention indicated will depend on the mechanism of the glaucoma.

Laser surgery
There are three types of laser surgery used in treating glaucoma: trabeculoplasty, iridotomy, and cycloablation.

Trabeculoplasty, usually performed with an Argon green laser, is the application of laser energy next to the drainage channels (trabecular meshwork) around the circumference of the iris inside the eye (the coloured part of the eye.) This is used only for open-angle types of glaucoma, especially chronic ("primary") open angle glaucoma, pseudoexfoliation glaucoma, or pigmentary glaucoma.

Pharmaceutical Management of Glaucoma


Reviewing the Major Classes of Antiglaucoma Medication

Catherine M. Birt, MA, MD, FRCSC
Sunnybrook & Women's College
Health Science Centre,
Assistant Professor,
University of Toronto

Medical management of glaucoma is a field that has expanded dramatically over the past five or six years. Since aging is one of the major risk factors for the development of glaucoma, it is an area that is of great relevance to anyone managing geriatric patients. The purpose of this article is to review the five major classes of antiglaucoma medications, the drugs that are currently available in each class, their indications and their side effects.

Glaucoma is considered to be an optic neuropathy with characteristic optic nerve damage (with loss of the neuroretinal rim and an increased cup-to-disc ratio) and visual field changes (with arcuate field defects progressing to complete loss of peripheral vision). Intraocular pressure (IOP) is not part of the definition of the disease, as many people with statistically elevated IOP do not develop the neuropathy, and many patients with statistically normal IOP do. Intraocular pressure is considered a major risk factor for the development of glaucoma. Other risk factors include advanced age, race, positive family history, myopia, and systemic factors such as diabetes and hypertension. Glaucoma is generally divided into open versus closed angle, and each of these can be subdivided into primary and secondary subtypes.