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Cutaneous Adverse Drug Reactions in Older Adults Part II: Management

G.A.E. Wong, MBChB, MRCP(UK), and N.H. Shear, MD, FRCP(C), Divisions of Dermatology and Clinical Pharmacology, Sunnybrook & Women’s College Health Sciences Centre, University of Toronto, Toronto, ON.

Cutaneous adverse drug reactions are a common problem affecting ambulatory and hospitalized patients. Older patients may be predisposed to adverse drug reactions due to inappropriate medication prescription, age-associated changes in pharmacokinetics and pharmacodynamics, altered homeostatic mechanisms, multiple medical pathologies, and use of drugs with a narrow therapeutic margin. In this second of two articles, the management of cutaneous adverse drug reactions
is reviewed.

Key words: adverse drug reaction, skin, cutaneous, rash, drug eruption, treatment, management.

Related Terms: Dermatology, Drug Safety, adverse drug reactions, cutaneous, drug eruption, management, rash, skin, treatment

Cutaneous Adverse Drug Reactions in Older Adults Part I: Assessment and Diagnosis

G.A.E. Wong, MBChB, MRCP (UK); N.H. Shear, MD, FRCP(C), Divisions of Dermatology and Clinical Pharmacology, Sunnybrook & Women’s College Health Sciences Centre, University of Toronto, Toronto, ON.

Cutaneous adverse drug reactions (ADR) are a common problem affecting ambulatory and hospitalized patients. Older patients may be more predisposed to ADR due to inappropriate prescribing of medications, age-associated changes in pharmacokinetics and pharmacodynamics, altered homeostatic mechanisms, multiple medical pathology and use of drugs with a narrow therapeutic margin. In this first of two articles, a practical approach to the assessment and diagnosis of patients with suspected drug-induced rashes will be described. A subsequent article will discuss the management of patients with cutaneous ADR.
Key words: adverse drug reaction, skin, rash, cutaneous, diagnosis, assessment.

Related Terms: Dermatology, adverse drug reactions, assessment, cutaneous, diagnosis, rash, skin
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